Topic Overview
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Drugs & Genetics: Why Do Some People Respond to Drugs Differently than Others?
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Drugs & Genetics: Why Do Some People Respond to Drugs Differently than Others?
Time Required
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Short (2-5 days)
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Prerequisites
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Basic understanding of what genes, DNA, and proteins are.
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Material Availability
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Readily available
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Cost
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Very Low (under $20)
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Safety
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No issues
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Abstract
From 2005 to 2008, 48% of everyone in the U.S. was using at least one prescription drug, and 21% of people were taking three or more drugs. People are prescribed drugs all the time, but prescriptions can be dangerous because people can have different responses to drugs. These responses largely have to do with genetic mutations. Why are some genetic mutations associated with a different response to a drug? In this science project, you will explore an online drug and genetics database to identify how a genetic mutation can be associated with how a person's body processes, and responds to, a certain drug.
Objective
Determine why some gene mutations cause people to respond differently to a drug.
Credits
Teisha Rowland, PhD, Science Buddies
Hypothesis and Variables
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If I find out why some people respond to drugs differently than others, then I can improve the way medication is dealt with in the world.
Constant:
+ Drug
Independent Variable:
+ Genes
Dependent Variable:
+ Gene's response to the drug
If I find out why some people respond to drugs differently than others, then I can improve the way medication is dealt with in the world.
Constant:
+ Drug
Independent Variable:
+ Genes
Dependent Variable:
+ Gene's response to the drug
Research Questions
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What I need to know:
- Definitions
- Importance of research
- Any current research projects
Equipment
- Computer with an internet connection
- PharmGKB online account
- lab notebook
Procedures - Find out the generic and trade names of a certain drug, the kind of chemical the drug is (draw the chemical structure), what other drugs it is related to, what medical condition the drug is used to treat, the drug's general effect on the body. Identify mutations in DNA that affect the response to the drug.
- Definitions
- Importance of research
- Any current research projects
Equipment
- Computer with an internet connection
- PharmGKB online account
- lab notebook
Procedures - Find out the generic and trade names of a certain drug, the kind of chemical the drug is (draw the chemical structure), what other drugs it is related to, what medical condition the drug is used to treat, the drug's general effect on the body. Identify mutations in DNA that affect the response to the drug.
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